NOVEL DRUG DELIVERY SYSTEM (NDDS) - PHARMACEUTICS
NOVEL DRUG DELIVERY SYSTEM - PHARMACEUTICS
Novel Drug Delivery System Aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action.
CONTENTS
1. DEFINITION OF NOVEL DRUG DELIVERY SYSTEM
2. SOME OF THE MODERN DOSAGE FORM IN NOVEL DRUG DELIVERY SYSTEM
DEFINITION OF NOVEL DRUG DELIVERY SYSTEM
What is NDDS?
- Novel Drug Delivery System Aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action.
- drugs are never administration in their pure form but are converted into a suitable formulation then administration and total duration of action can be checked according to the need
Also, Read;- Dosage Forms Notes
SOME OF THE MORDEN DOSAGE FORMS ARE
1. IMPLANTS
2. FILMS AND STRIPS
3. LIPOSOME DRUG CARRIERS
4. CONTROLLED DRUG DELIVERY METHOD
5. ERYTHROCYTES
6. NANOPARTICLES
7. PRO-DRUGS
what is the implant? Novel Drug Delivery System
1. IMPLANTS
- the hypodermic tablets are placed under the skin by a minor surgery
- for the purpose of release drugs over a prolonged period of time
- now the days magnetically controlled implants have been developed
- which can open or closed order to release or top the drug
- implants are in capsule form made by body and cap
- the implants are placed in the upper thigh at 5mm.
- these implants are useful in hormone therapy
- it remains open and releases the medicament but the capsule gets closed soon as the magnet is removed
Also Read: Acid Bases Notes
What are film and strips? Novel Drug Delivery System
2. FILMS AND STRIPS
- these are meant for topical application for slow release of drug and predetermined period of time
- films and strips popular these days are -
A. ZERO ORDER RELEASE FILMS
B. BUCCAL STRIPS
C. SPRAY BANDAGES
what are zero-order release films? Novel Drug Delivery System
A . ZERO ORDER RELEASE FILMS
- these films are also called 'laminates' and are meant for topical application
- nitroglycerin laminates are prepare by mixing propylene glycerin with about 1% carbopol resin
- the mixture is neutralized with sodium hydroxide solution and then 0.1% of Nitroglycerin is added
- it is the placed between polythene sheets 5×5cm
- edges are sealed by heat
- laminates release the drug slowly into circulation about 12 hours
- pilocarpine films are prepared by acrylates and methacrylates
Also Read: What are Alkaloids?
what are buccal strips? Novel Drug Delivery System
B. BUCCAL STRIPS
- the buccal and sublingual tablets now replaced with buccal strips
- strips are consisted of thin absorbents base of fabrics, filter paper, and cotton, etc
- buccal strips prepared by immersing a long piece of fabric
- the buccal strips is made with buccal mucosa about 15 mint and then it is removed and discarded
what is spray bandages? Novel Drug Delivery System
C. SPRAY BANDAGES
- spray bandages are prepare by spraying the solution of drug in polylactide
- a 20%of purified Lactide polymers is made in chloroform
- drug concentration of 0.01 to 90% is dissolved or dispersed
-some solution is packed in aerosol containers having a suitable propellant such as dichloro di-fluoro methane
-this solution is sprayed it will be a comfortable bandage
- simply wash with warm water
Also Read:- Antidiabetic Drug
What is liopsome drug carries? Novel Drug Delivery System
3. LIPOSOME DRUG CARRIERS
- Liposome are used as carriers for controlled drug delivery, which decreases toxic effects of drugs in the body; the drug will be protected from the external environment, and hence won't target unintended tissues Also, it is hard to sterilize liposomes since phospholipids' bilayer is sensitive to heat.
Application of liposome learn from another pharmaceutics book
4.CONTROLLED DRUG DELIVERY MODULES ( CDDM )
- CDDM are devices which formed by embedding
- the drug within a polymeric matrix release slowly to the body very long period of time
- poly-neric matrics used to hold the drug reversibly are polyethylene, silicone and cellulose esters.
- CDDM can be applied skin, implanted, subcutaneous or inserted into various part of body cavities
5. ERYTHROCYTES
Novel Drug Delivery System
- erythrocytes also tried in order to achieve control release of drugs
- life span 120 days
- erythrocytes allow a drug to circulate in the body for a long time
- helps in the slow release of drug in serum
- when the drug is encapsulated in erythrocytes, the drug gets leaked out of the cells
- resealed erythrocytes are prepared by putting them into a hypo tonics medium
- they can be swollen
- erythrocytes may be suspended in normal saline solution for preparing injections
- the techniques can be used on commercial scale only if erythrocytes are made available in test tubes
Application - I am recommended you to read Book of RM Mehta)
6. NANOPARTICLES
Novel Drug Delivery System
- it is based on colloidal drug delivery system.
- the particle size of this system is nano meter range for example 200-500mm. it is called nanoparticles
- in this system carrier are helped deposit the drug at the target size
- the carrier used are naturally like human serum albumin, bovine serum albumin , and other substances like gelatin ,casein and ethyl cellulose.
- method of preparation nanoparticles is similar to coacervation phase separation
- these nanoparticles may be hard, isolated, and dried for storage
- nanoparticles can be dispersed in an aqueous system
Applications of nanoparticles- I am recommended you to read Book of RM Mehta)
7. PRO-DRUGS
Novel Drug Delivery System
- the compound which undergo biotransformation before showing desired pharmacological activity are called pro-drugs or pro-agents
- pro-drugs are generally the esters or amides of parent drugs.
- pro-drugs are useful in improving the solubility, stability, bioavailability of drugs
- masking the unpleasant taste and odour of thr parent drug and reducing the drug toxicity
(You can read deeply in your pharmaceutics books. I am recommended you to read RM Mehta)
Thank you☺
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